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Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

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dc.contributor.author Escribá Ruiz, Pablo Vicente
dc.contributor.author Busquets Xaubet, Xavier
dc.contributor.author Inokuchi, Jin-ichi
dc.contributor.author Balogh, Gábor
dc.contributor.author Török, Zsolt
dc.contributor.author Ibolya, Horváth
dc.contributor.author Harwood, John L.
dc.contributor.author Vígh, László
dc.date.accessioned 2018-11-08T13:37:13Z
dc.identifier.uri http://hdl.handle.net/11201/148491
dc.description.abstract [eng] Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein-lipid structures and microdomains that serve as functional platforms for interacting signaling lipids and proteins. Membrane lipids and lipid structures participate directly as messengers or regulators of signal transduction. In addition, protein-lipid interactions participate in the localization of signaling protein partners to specific membrane microdomains. Thus, lipid alterations change cell signaling that are associated with a variety of diseases including cancer, obesity, neurodegenerative disorders, cardiovascular pathologies, etc. This article reviews the newly emerging field of membrane lipid therapy which involves the pharmacological regulation of membrane lipid composition and structure for the treatment of diseases. Membrane lipid therapy proposes the use of new molecules specifically designed to modify membrane lipid structures and microdomains as pharmaceutical disease-modifying agents by reversing the malfunction or altering the expression of disease-specific protein or lipid signal cascades. Here, we provide an in-depth analysis of this emerging field, especially its molecular bases and its relevance to the development of innovative therapeutic approaches.
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a: https://doi.org/10.1016/j.plipres.2015.04.003
dc.relation.ispartof Progress in Lipid Research, 2015, vol. 59, p. 38-53
dc.subject.classification 57 - Biologia
dc.subject.other 57 - Biological sciences in general
dc.title Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion
dc.date.updated 2018-11-08T13:37:13Z
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2075-01-01
dc.embargo 2075-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.identifier.doi https://doi.org/10.1016/j.plipres.2015.04.003


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