Multicomponent crystalline forms of the modified nucleobases: 1-ethyluracil and 9-ethyladenine

Abstract

[eng] In the present work the ability of two modified nucleobases, 1-ethyluracil and 9-ethyladenine, to form multicomponent crystalline compounds such as cocrystals and/or salts has been addressed. Grinding methods were explored in a first attempt. Then in order to obtain suitable single crystals for structure resolution, solvent cocrystallizations were performed. Through the physico-chemical characterization and the analysis of the molecular arrangements for the new compounds, the effect of the different coformers on the resulting interactions/synthons have been studied, which is fundamental in crystal engineering.