[cat] L’avanç amb l’edat afecta les capacitats cognitives i motores de les persones, deteriorant la seva qualitat de vida. Aquestes alteracions augmenten la predisposició a trastorns neurodegeneratius i psiquiàtrics. Tot i que no es coneixen completament els processos que ocorren en l’envelliment, es creu que l’estrès oxidatiu té un paper important. En aquesta línia, els polifenols, que presenten propietats antiinflamatòries i antioxidants, podrien actuar prevenint o retardant els efectes associats a l’edat a nivell cerebral. En aquest experiment es va plantejar que la cervesa, una beguda rica en polifenols, pogués tenir un efecte neuroprotector sobre els sistemes monoaminèrgics, i si aquest efecte era diferent segons el tipus de consum. Per això, els animals es van distribuir en 3 tractaments: control (aigua), consum continuat (cervesa diàriament) i consum abusiu (2 dies exclusivament cervesa). A més, dins els grups del consum es va diferenciar entre cervesa amb alcohol i sense alcohol. Es van analitzar mitjançant HPLC, la síntesi, l’acumulació de neurotransmissors monoaminèrgics i el metabolisme d’aquests. Els resultats obtinguts suggereixen que el consum continuat i moderat de cervesa presenta efectes neuroprotectors sobre els sistemes dopaminèrgics de l’estriat i serotoninèrgics de l’estriat i l’hipocamp. A més, aquest efecte es veuria tant en la cervesa amb alcohol com sense alcohol. Per contra, el consum abusiu s’equipararia al grup control, pel que no presentaria propietats beneficioses sobre els sistemes monoaminèrgics.
[eng] Advancing age affects people's cognitive and motor skills, that deteriorate their quality of life. These alterations increase the predisposition to neurodegenerative and psychiatric disorders. Although the processes that occur in aging are not fully understood, oxidative stress is thought to play an important role. In this line, polyphenols, which have anti-inflammatory and antioxidant properties, could act by preventing or delaying the effects associated with age in the brain. In this experiment it was suggested that beer, a beverage rich in polyphenols, could have a neuroprotective effect on monoaminergic systems, and whether this effect was different depending on the type of consumption. Therefore, the animals were distributed in 3 treatments: control (water), continuous consumption (beer daily) and abusive consumption (2 days exclusively beer). In addition, within consumption groups a distinction was made between alcoholic and non-alcoholic beer. The synthesis, accumulation of monoaminergic neurotransmitters and their metabolism were analysed by HPLC. The results suggest that continued and moderate beer consumption has neuroprotective effects on the dopaminergic systems of the striatum and serotonergic systems of the striatum and hippocampus. In addition, this effect would be seen in both alcoholic and non-alcoholic beer. In contrast, abusive consumption would be equated with the control group, so it would not have beneficial properties on monoaminergic systems.