[eng] Plum pox virus (PPV), the causal agent of sharka disease, is one of the most studied plant viruses, and major advances</p><p>in detection techniques, genome characterization and organization, gene expression, transmission, and the description</p><p>of candidate genes involved in PPV resistance have been described. However, information concerning the plant</p><p>response to PPV infection is very scarce. In this review, we provide an updated summary of the research carried out</p><p>to date in order to elucidate how plants cope with PPV infection and their response at different levels, including the</p><p>physiological, biochemical, proteomic, and genetic levels. Knowledge about how plants respond to PPV infection can</p><p>contribute to the development of new strategies to cope with this disease. Due to the fact that PPV induces an oxidative</p><p>stress in plants, the bio-fortification of the antioxidative defences, by classical or biotechnological approaches,</p><p>would be a useful tool to cope with PPV infection. Nevertheless, there are still some gaps in knowledge related to</p><p>PPV–plant interaction that remain to be filled, such as the effect of PPV on the hormonal profile of the plant or on the</p><p>plant metabolome.</p>