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A randomized, double-blind, sham-controlled trial of transcranial direct current stimulation in attention-deficit/hyperactivity disorder

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dc.contributor.author Cosmo, Camila
dc.contributor.author Baptista, Abrahão Fontes
dc.contributor.author Araújo, Arão Nogueira de
dc.contributor.author Rosário, Raphael Silva do
dc.contributor.author Miranda, José Garcia Vivas
dc.contributor.author Montoya Jiménez, Pedro José
dc.contributor.author Sena, Eduardo Pondé de
dc.date.accessioned 2016-01-28T08:32:11Z
dc.date.available 2016-01-28T08:32:11Z
dc.date.issued 2015-08-12
dc.identifier.citation 1932-6203
dc.identifier.uri http://hdl.handle.net/11201/1710
dc.description.abstract BACKGROUND: Current standardized treatments for cognitive impairment in attention-deficit/hyperactivity disorder remain limited and their efficacy restricted. Transcranial direct current stimulation (tDCS) is a promising tool for enhancing cognitive performance in several neuropsychiatric disorders. Nevertheless, the effects of tDCS in reducing cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD) have not yet been investigated. METHODS: A parallel, randomized, double-blind, sham-controlled trial was conducted to examine the efficacy of tDCS on the modulation of inhibitory control in adults with ADHD. Thirty patients were randomly allocated to each group and performed a go/no-go task before and after a single session of either anodal stimulation (1 mA) over the left dorsolateral prefrontal cortex or sham stimulation. RESULTS: A nonparametric two-sample Wilcoxon rank-sum (Mann-Whitney) test revealed no significant differences between the two groups of individuals with ADHD (tDCS vs. sham) in regard to behavioral performance in the go/no go tasks. Furthermore, the effect sizes of group differences after treatment for the primary outcome measures-correct responses, impulsivity and omission errors-were small. No adverse events resulting from stimulation were reported. CONCLUSION: According to these findings, there is no evidence in support of the use of anodal stimulation over the left dorsolateral prefrontal cortex as an approach for improving inhibitory control in ADHD patients. To the best of our knowledge, this is the first clinical study to assess the cognitive effects of tDCS in individuals with ADHD. Further research is needed to assess the clinical efficacy of tDCS in this population.
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.isformatof Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0135371
dc.relation.ispartof Plos One, 2015, vol. 10, num. 8, p. e0135371
dc.rights cc-by (c) Cosmo, Camila et al., 2015
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification Psicologia
dc.subject.classification Biologia
dc.subject.other Psychology
dc.subject.other Biology
dc.title A randomized, double-blind, sham-controlled trial of transcranial direct current stimulation in attention-deficit/hyperactivity disorder
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-01-28T08:32:12Z
dc.subject.keywords ADHD
dc.subject.keywords tDCS
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0135371


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cc-by (c) Cosmo, Camila et al., 2015 Except where otherwise noted, this item's license is described as cc-by (c) Cosmo, Camila et al., 2015

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