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La vía de las lectinas en lupus y tuberculosis: polimorfismos de la MBL2 y MASP2, beneficiosos o perjudiciales/ The lectin pathway in lupus and tuberculosis: MBL2 and MASP2 polymorphisms, beneficial or harmful

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dc.contributor García Gasalla, Mercedes
dc.contributor Grases Freixedas, Fèlix
dc.contributor Institut Universitari d'Investigació en Ciències de la Salut
dc.creator Losada López, Inés
dc.date 2014
dc.date.accessioned 2017-07-10T09:37:07Z
dc.date.available 2017-07-10T09:37:07Z
dc.identifier http://ibdigital.uib.cat/greenstone/collect/tesisUIB/index/assoc/Losada_L.dir/Losada_Lopez_Ines.pdf
dc.identifier.uri http://hdl.handle.net/11201/2640
dc.description [eng] MBL2 exon 1, promoter genotyping and serum MBL concentrations were determined in TB patients (79) and HHC (120) and in SLE cases (39) and controls (59). MASP-2 serum levels and 5 polymorphisms in MASP2 gene were also analyzed in 49 TB patients and 50 HHC and in the same SLE cases and controls as before. LXPA/HYPA, high MBL producer diplotype was significantly more frequent in HHC than in patients (16.8% vs 6.4%, p=0.03). Higher MBL levels were found in active TB than in HHC (median MBL 3420ng/mL &#091;10-28415&#093; and 2600 ng/mL &#091;5-20000&#093; respectively, p=0.02). In the SLE study LYQC/HYPD, LXPA/LYQC and LYPB/HYPD were only found in SLE patients, related to severe MBL deficiency (<100ng/mL). There was a strong correlation between MBL2 Exon 1 and promoter genotype and MBL levels. Asp105Gly MASP2 variant was the only detected among; no relationship was found between the variant and TB or SLE.
dc.description [spa] Se determinaron genotipos del exon 1 y del promotor MBL2 y concentraciones de MBL en pacientes con tuberculosis (79) y contactos sanos (120), y en pacientes con lupus (39) y controles (59). Se analizaron niveles de MASP-2 y 5 polimorfismos de MASP2 en 40 tuberculosis y 50 contactos y en los mismos pacientes con lupus y sanos analizados previamente LXPA/HYPA, productor de altos niveles de MBL fue más frecuente en contactos que en pacientes (16.8% vs 6.4%, p=0.03). Niveles más altos de MBL se encontraron en tuberculosis que en contactos (3420ng/mL &#091;10-28415&#093; y 2600 ng/mL &#091;5-20000&#093; respectivamente, p=0.02). En el estudio de lupus LYQC/HYPD, LXPA/LYQC y LYPB/HYPD se encontraron sólo en lupus; se relacionaron con déficit grave de MBL(<100ng/mL). Hubo relación entre genotipos del Exon 1 y del promoter y niveles de MBL. La variante Asp105Gly de MASP2 fue la única encontrada; no se observó relación con tuberculosis o lupus.
dc.format application/pdf
dc.language eng
dc.publisher Universitat de les Illes Balears
dc.relation Tesis doctorals de la UIB
dc.rights all rights reserved
dc.rights info:eu-repo/semantics/openAccess
dc.subject Biomedical Sciences
dc.subject Mannose binding lectin, Mannose associated serine protease, polymorphisms, lupus, tuberculosis
dc.subject Manosa asociada a lectina, mannosas asociadas a serinproteasa, polimorfismos, lupus, tuberculosis
dc.title La vía de las lectinas en lupus y tuberculosis: polimorfismos de la MBL2 y MASP2, beneficiosos o perjudiciales/ The lectin pathway in lupus and tuberculosis: MBL2 and MASP2 polymorphisms, beneficial or harmful
dc.type info:eu-repo/semantics/doctoralThesis
dc.type info:eu-repo/semantics/publishedVersion


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