Dietary Supplementation of Calcium may Counteract Obesity in Mice Mediated by Changes in Plasma Fatty Acids

Show simple item record Laraichi, S. Parra, P. Zamanillo Campos, Rocío El Amarti, A. Palou, A. Serra, F. 2015-02-23T09:26:01Z 2015-02-23T09:26:01Z 2013-06-01
dc.identifier.citation 0024-4201
dc.description.abstract The scope of this study was to assess the impact of calcium and conjugated linoleic acid (CLA) supplementation on plasma fatty acid profiles and to evaluate potential synergistic effects of both compounds against dietary obesity. Mice separated into five experimental groups were followed: control (C), high-fat diet (HF), HF with calcium (Ca), HF plus CLA and HF with both Ca and CLA. Plasma metabolites and fatty acids were determined by commercial kits and gas chromatography, respectively. Both dietary calcium and CLA supplementation contributed to lower body fat gain under a HF diet. Maximum efficacy was seen with calcium; no additional effect was associated with the combined treatment with CLA. Plasma leptin, adiponectin and HOMA index were in accordance with an altered glucose/insulin homeostasis in the HF and HF + CLA groups, whereas control levels were attained under Ca-enriched diets. Plasma fatty acids showed minor changes associated to CLA treatment, but a high impact on PUFA was observed under Ca-enriched diets. Our results show that the mechanism underlying the anti-obesity effects of calcium supplementation is mediated mainly by changes in PUFA plasma profile. In addition, the lack of synergy on body weight reduction in combination with associated lipid profiles of calcium and CLA suggests that calcium may interfere with absorption and/or bioactivity of CLA, which can be of relevance when using CLA-fortified dairy products against human obesity.
dc.language.iso eng
dc.relation.isformatof Versió postprint del document publicat a: 10.1007/s11745-013-3798-y
dc.relation.ispartof Lipids, 2013, vol. 48, num. 8, p. 817-826
dc.title Dietary Supplementation of Calcium may Counteract Obesity in Mice Mediated by Changes in Plasma Fatty Acids
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion 2015-02-23T09:26:02Z

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Repository

Advanced Search


My Account