Intake of melatonin increases tryptophan hydroxylase type 1 activity in aged rats: Preliminary study

Show simple item record Moranta Mesquida, David Barceló, Pere Aparicio Martínez, Sara Garau, C. Sarubbo, Maria Fiorella Ramis Escudero, Margarita Rosa Nicolau Llobera, María Cristina Esteban Valdés, Susana Cristina 2018-09-18T07:36:32Z
dc.description.abstract [eng] Pineal melatonin is important not only for synchronization of biological rhythms, but also in the ageing process as a potential drug to relieve oxidative damage. During ageing, the nocturnal melatonin production decreases resulting in an increased incidence of disorders. Present in vivo experimentswere performed to study the effects of exogenous melatonin chronically administered to old rats on the pineal biosynthesis of melatonin and the precursor serotonin (5-HT) mediated by tryptophan hydroxylase type 1 (TPH-1). Accumulation of 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition was used as a measure of the TPH-1 activity. 5-HT and its metabolite 5-HIAA were also quantified by HPLC-ED. As expected, ageing resulted inworsening of different neurochemical parameters. However, chronic intake of melatonin (1 mg/kg/day, diluted in drinking water, 4 weeks) increased TPH-1 activity and significantly improved the age-induced deficits in nocturnal melatonin content in the pineal gland. Results suggest that melatonin intake (or melatonin rich foods) may contribute to recover the pineal function preventing the nocturnal descent of 5-HT and melatonin biosynthesis that normally occur in pineal gland as a consequence of ageing.
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a:
dc.relation.ispartof Experimental Gerontology, 2013, vol. 49, p. 1-4
dc.rights (c) Elsevier, 2013
dc.subject.classification 612 - Fisiologia
dc.subject.other 612 - Physiology. Human and comparative physiology
dc.title Intake of melatonin increases tryptophan hydroxylase type 1 activity in aged rats: Preliminary study
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion 2018-09-18T07:36:32Z info:eu-repo/date/embargoEnd/2075-01-01
dc.embargo 2075-01-01
dc.subject.keywords working memory
dc.subject.keywords melatonin
dc.subject.keywords aging
dc.subject.keywords tryptophan depletion
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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