dc.contributor.author |
Esteban Valdés, Susana Cristina
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dc.contributor.author |
Moranta Mesquida, David
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dc.contributor.author |
Sastre-Coll, Antonio
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dc.contributor.author |
Miralles Socías, Antonio
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dc.contributor.author |
García-Sevilla, Jesús Andrés
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dc.date.accessioned |
2018-09-18T09:16:44Z |
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dc.identifier.uri |
http://hdl.handle.net/11201/147495 |
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dc.description.abstract |
[eng] The in vivo sensitivity of presynaptic 5-HT1A receptors (autoreceptors and heteroreceptors) modulating the synthesis of 5-hydroxytryptophan/serotonin (5-HTP/5-HT) and 3,4-dihydroxyphenylalanine/dopamine (DOPA/DA) in rat brain was investigated after ethanol treatment and withdrawal. In saline-treated rats as well as in acute ethanol (2 g/kg, intraperitoneally (i.p.), 2 h)- and chronic ethanol (2 g/kg for 7 days)-treated rats, a low dose of the 5-HT1A receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT; 0.1 mg/kg, i.p., 1 h) did not decrease the synthesis of 5-HTP in brain (except modestly in striatum; 20% after the chronic treatment) or that of DOPA in striatum. In contrast, in chronic ethanolwithdrawn rats (24 h), 8-OH-DPAT significantly decreased the synthesis of 5-HTP in the hippocampus (29%), cerebral cortex (41%) and striatum (33%) and that of DOPA in the striatum (28%). Similar effects were induced by the mixed 5-HT1A agonist/D2 antagonist buspirone (1 mg/kg, i.p., 1 h) which also decreased 5-HTP synthesis in the hippocampus (24%), cerebral cortex (36%) and striatum (35%) of chronic ethanol-withdrawn rats. These results indicate that chronic ethanol and more clearly the spontaneous withdrawal from chronic ethanol induce supersensitivity of 5-HT1A-auto/heteroreceptors modulating the synthesis of 5-HT and DA in rat brain. |
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dc.format |
application/pdf |
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dc.relation.isformatof |
Versió postprint del document publicat a: |
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dc.relation.ispartof |
Neuroscience Letters, 2002, vol. 326, num. 2, p. 121-124 |
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dc.rights |
(c) Elsevier Ireland Ltd., 2002 |
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dc.title |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo |
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dc.type |
info:eu-repo/semantics/article |
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dc.type |
info:eu-repo/semantics/acceptedVersion |
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dc.date.updated |
2018-09-18T09:16:44Z |
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dc.date.embargoEndDate |
info:eu-repo/date/embargoEnd/2075-01-01 |
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dc.embargo |
2075-01-01 |
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dc.subject.keywords |
etanol |
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dc.subject.keywords |
síndrome de abstinència |
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dc.subject.keywords |
receptors per a serotonina |
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dc.rights.accessRights |
info:eu-repo/semantics/embargoedAccess |
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