Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo

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dc.contributor.author Esteban Valdés, Susana Cristina
dc.contributor.author Moranta Mesquida, David
dc.contributor.author Sastre-Coll, Antonio
dc.contributor.author Miralles Socías, Antonio
dc.contributor.author García-Sevilla, Jesús Andrés
dc.date.accessioned 2018-09-18T09:16:44Z
dc.identifier.uri http://hdl.handle.net/11201/147495
dc.description.abstract [eng] The in vivo sensitivity of presynaptic 5-HT1A receptors (autoreceptors and heteroreceptors) modulating the synthesis of 5-hydroxytryptophan/serotonin (5-HTP/5-HT) and 3,4-dihydroxyphenylalanine/dopamine (DOPA/DA) in rat brain was investigated after ethanol treatment and withdrawal. In saline-treated rats as well as in acute ethanol (2 g/kg, intraperitoneally (i.p.), 2 h)- and chronic ethanol (2 g/kg for 7 days)-treated rats, a low dose of the 5-HT1A receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT; 0.1 mg/kg, i.p., 1 h) did not decrease the synthesis of 5-HTP in brain (except modestly in striatum; 20% after the chronic treatment) or that of DOPA in striatum. In contrast, in chronic ethanolwithdrawn rats (24 h), 8-OH-DPAT significantly decreased the synthesis of 5-HTP in the hippocampus (29%), cerebral cortex (41%) and striatum (33%) and that of DOPA in the striatum (28%). Similar effects were induced by the mixed 5-HT1A agonist/D2 antagonist buspirone (1 mg/kg, i.p., 1 h) which also decreased 5-HTP synthesis in the hippocampus (24%), cerebral cortex (36%) and striatum (35%) of chronic ethanol-withdrawn rats. These results indicate that chronic ethanol and more clearly the spontaneous withdrawal from chronic ethanol induce supersensitivity of 5-HT1A-auto/heteroreceptors modulating the synthesis of 5-HT and DA in rat brain.
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a:
dc.relation.ispartof Neuroscience Letters, 2002, vol. 326, num. 2, p. 121-124
dc.rights (c) Elsevier Ireland Ltd., 2002
dc.title Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion
dc.date.updated 2018-09-18T09:16:44Z
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2075-01-01
dc.embargo 2075-01-01
dc.subject.keywords etanol
dc.subject.keywords síndrome de abstinència
dc.subject.keywords receptors per a serotonina
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess


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