Is there a pathogenic role for mitochondria in Parkinson's disease?

Show simple item record Vives-Bauza, Cristòfol de Vries, Rosa L.A. Tocilescu, Maja Alejksandra Przedborski Serge 2018-10-08T09:51:14Z
dc.description.abstract [eng] Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. For decades, a deficit in mitochondrial respiration was thought to be a key factor in PD neurodegeneration. However, excluding a few exceptions where a clinical picture of parkinsonism is associated with a mitochondrial DNA mutation, preclinical and clinical studies have failed to identify any genetic mutations in the genes encoding for the electron transport chain complexes in PD patients. More recently, it has been discovered that mutations in the genes encoding for Parkin, PINK1 and DJ1 are associated with familial forms of PD and with mitochondrial alterations, including morphological abnormalities. These results have led many researchers to revisit the question of mitochondrial biology as a primary mechanism in PD pathogenesis, this time from an angle of perturbation in mitochondrial dynamics and not from the angle of a deficit in respiration. en
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a:
dc.relation.ispartof Parkinsonism & Related Disorders, 2009, vol. 15, num. Suppl 3, p. S241-S244
dc.subject.classification 616.8 - Neurologia. Neuropatologia. Sistema nerviós
dc.subject.other 616.8 - Neurology. Neuropathology. Nervous system
dc.title Is there a pathogenic role for mitochondria in Parkinson's disease?
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion 2018-10-08T09:51:14Z info:eu-repo/date/embargoEnd/2075-01-01
dc.embargo 2075-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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