Molecular modeling and chemical reactivity of sanfetrinem and derivatives

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dc.contributor.author Fasoli, Hector J.
dc.contributor.author Frau Munar, Juan
dc.contributor.author Fenollar Ferrer, Cristina
dc.contributor.author Muñoz Izquierdo, Juan
dc.contributor.author Donoso Pardo, Josefa Laurentina
dc.date.accessioned 2018-11-12T10:48:16Z
dc.identifier.uri http://hdl.handle.net/11201/148501
dc.description.abstract [eng] The indiscriminate use of beta-lactams has considerably diminished their efficiency as a result of bacteria developing effective defense mechanisms against them. Recent pharmaceutical research has led to the synthesis of tricyclic â-lactam antibiotics known as 'tricyclic carbapenems' or 'trinems'. In this work, we studied the chemical reactivity, an essential property for antibiotic action, of trinems and found it to be similar to that of cephalosporins. Also, we elucidated the interaction pattern for sanfetrinem and 4â-methoxy trinem and compared it to that for classical â-lactams. The behavior of both trinems was found to be similar to that of penicillin G toward Staphylococcus aureus PC1, and that of cephalothin and imipenem toward Enterobacter cloacae P99.
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dc.relation.isformatof Versió postprint del document publicat a: https://doi.org/10.1021/jp044192m
dc.relation.ispartof Journal of Physical Chemistry B, 2005, vol. 109, p. 9780-9786
dc.subject.classification 54 - Química
dc.subject.other 54 - Chemistry. Crystallography. Mineralogy
dc.title Molecular modeling and chemical reactivity of sanfetrinem and derivatives
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion
dc.date.updated 2018-11-12T10:48:16Z
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2075-01-01
dc.embargo 2075-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.identifier.doi https://doi.org/10.1021/jp044192m


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