GPER mediates the effects of 17β-estradiol in cardiac mitochondrial biogenesis and function

Show simple item record Sbert Roig, Miquel Bauzá Thorbrügge, Marcos Galmés Pascual, Isabel Capllonch Amer, Gabriela García Palmer, Francisco José Lladó Sampol, Isabel Proenza Arenas, Ana María Gianotti Bauzá, Magdalena 2018-12-05T12:02:41Z
dc.description.abstract [eng] Considering the sexual dimorphism described in cardiac mitochondrial function and oxidative stress, we aimed to Investigate the role of 17β-estradiol (E2) in these sex differences and the contribution of E2 receptors to these effects. As a model of chronic deprivation of ovarian hormones, we used ovariectomized (OVX) rats, half of which were treated with E2. Ovariectomy decreased markers of cardiac mitochondrial biogenesis and function and also increased oxidative stress, whereas E2 counteracted these effects. In H9c2 cardiomyocytes we observed that G-protein coupled estrogen receptor (GPER) agonist mimicked the effects of E2 in enhancing mitochondrial function and biogenesis, whereas GPER inhibitor neutralized them. These data suggest that E2 enhances mitochondrial function and decreases oxidative stress in cardiac muscle, thus it could be responsible for the sexual dimorphism observed in mitochondrial biogenesis and function in this tissue. These effects seem to be mediated through GPER stimulation
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a:
dc.relation.ispartof Molecular and Cellular Endocrinology, 2016, vol. 420, p. 116-124
dc.subject.classification 57 - Biologia
dc.subject.other 57 - Biological sciences in general
dc.title GPER mediates the effects of 17β-estradiol in cardiac mitochondrial biogenesis and function
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion 2018-12-05T12:02:41Z info:eu-repo/date/embargoEnd/2075-01-01
dc.embargo 2075-01-01
dc.subject.keywords cardiac muscle
dc.subject.keywords 17β-estradiol
dc.subject.keywords Mitochondrial Biogenesis
dc.subject.keywords oxidative stress
dc.subject.keywords GPER
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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