Mitophagy: the latest problem for Parkinson's disease

Show simple item record Vives-Bauzà, Cristòfol Przedborski, Serge 2019-01-16T14:52:25Z 2019-01-16T14:52:25Z
dc.description.abstract [eng] Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. Some familial forms of PD are provoked by mutations in the genes encoding for the PTEN (phosphatase and tensin homolog)-induced putative kinase-1 (PINK1) and Parkin. Mounting evidence indicates that PINK1 and Parkin might function in concert to modulate mitochondrial degradation, termed mitophagy. However, the molecular mechanisms by which PINK1/Parkin affect mitophagy are just beginning to be elucidated. Herein, we review the main advances in our understanding of the PINK1/Parkin pathway. Because of the phenotypic similarities among the different forms of PD, a better understanding of PINK1/Parkin biology might have far-reaching pathogenic and therapeutic implications for both the inherited and the sporadic forms of PD.
dc.format application/pdf
dc.relation.ispartof Trends in Molecular Medicine, 2010, vol. 17, num. 3, p. 158-165
dc.rights , 2010
dc.subject.classification 57 - Biologia
dc.subject.other 57 - Biological sciences in general
dc.title Mitophagy: the latest problem for Parkinson's disease
dc.type info:eu-repo/semantics/article 2019-01-16T14:52:25Z
dc.rights.accessRights info:eu-repo/semantics/openAccess

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