Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response.

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dc.contributor.author March, Catalina
dc.contributor.author Regueiro, Verónica
dc.contributor.author Llobet Brossa, Enrique
dc.contributor.author Moranta Mesquida, David
dc.contributor.author Morey, Pau
dc.contributor.author Garmendia, Junkal
dc.contributor.author Bengoechea Alonso, José Antonio
dc.date.accessioned 2015-09-29T12:56:45Z
dc.date.available 2015-09-29T12:56:45Z
dc.date.issued 2010-04-07
dc.identifier.citation 1932-6203
dc.identifier.uri http://hdl.handle.net/11201/1490
dc.description.abstract Infected airway epithelial cells up-regulate the expression of chemokines, chiefly IL-8, and antimicrobial molecules including b-defensins (BD). Acinetobacter baumannii is a cause of hospital-acquired pneumonia. We examined whether A. baumannii induced the expressions of IL-8 and BD2 by airway epithelial cells and the receptors implicated in bacterial detection. A549 and human primary airway cells released IL-8 upon infection. A. baumannii-infected cells also increased the expression of BD2 which killed A. baummannii strains. IL-8 induction was via NF-kB and mitogen-activated kinases p38 and p44/42- dependent pathways. A. baumannii engaged Toll-like receptor (TLR) 2 and TLR4 pathways and A549 cells could use soluble CD14 as TLRs co-receptor. A. baumannii lipopolysaccharide stimulated IL-8 release by A549 cells and sCD14 facilitated the recognition of the lipopolysaccharide. Mass spectrometry analysis revealed that A. baumannii lipid A structure matches those with endotoxic potential. These results demonstrate that airway epithelial cells produce mediators important for A. baumannii clearance.
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.isformatof Reproducció del document publicat a: 10.1371/journal.pone.0010033
dc.relation.ispartof Plos One, 2010, vol. 5, num. 4, p. e1033
dc.rights cc-by (c) March, Catalina et al., 2010
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.title Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response.
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2015-09-29T12:56:46Z
dc.rights.accessRights info:eu-repo/semantics/openAccess

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cc-by (c) March, Catalina et al., 2010 Except where otherwise noted, this item's license is described as cc-by (c) March, Catalina et al., 2010

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