dc.contributor.author |
Losada López, Inés
|
|
dc.date |
2014 |
|
dc.date.accessioned |
2019-03-29T12:51:31Z |
|
dc.date.available |
2019-03-29T12:51:31Z |
|
dc.date.issued |
2019-03-29 |
|
dc.identifier.uri |
http://hdl.handle.net/11201/149213 |
|
dc.description.abstract |
[eng] MBL2 exon 1, promoter genotyping and serum MBL concentrations were determined in TB patients (79) and HHC (120) and in SLE cases (39) and controls (59). MASP-2 serum levels and 5 polymorphisms in MASP2 gene were also analyzed in 49 TB patients and 50 HHC and in the same SLE cases and controls as before.
LXPA/HYPA, high MBL producer diplotype was significantly more frequent in HHC than in patients (16.8% vs 6.4%, p=0.03). Higher MBL levels were found in active TB than in HHC (median MBL 3420ng/mL [10-28415] and 2600 ng/mL [5-20000] respectively, p=0.02).
In the SLE study LYQC/HYPD, LXPA/LYQC and LYPB/HYPD were only found in SLE patients, related to severe MBL deficiency (<100ng/mL).
There was a strong correlation between MBL2 Exon 1 and promoter genotype and MBL levels. Asp105Gly MASP2 variant was the only detected among; no relationship was found between the variant and TB or SLE. |
ca |
dc.description.abstract |
[spa] Se determinaron genotipos del exon 1 y del promotor MBL2 y concentraciones de MBL en pacientes con tuberculosis (79) y contactos sanos (120), y en pacientes con lupus (39) y controles (59). Se analizaron niveles de MASP-2 y 5 polimorfismos de MASP2 en 40 tuberculosis y 50 contactos y en los mismos pacientes con lupus y sanos analizados previamente
LXPA/HYPA, productor de altos niveles de MBL fue más frecuente en contactos que en pacientes (16.8% vs 6.4%, p=0.03). Niveles más altos de MBL se encontraron en tuberculosis que en contactos (3420ng/mL [10-28415] y 2600 ng/mL [5-20000] respectivamente, p=0.02).
En el estudio de lupus LYQC/HYPD, LXPA/LYQC y LYPB/HYPD se encontraron sólo en lupus; se relacionaron con déficit grave de MBL(<100ng/mL).
Hubo relación entre genotipos del Exon 1 y del promoter y niveles de MBL. La variante Asp105Gly de MASP2 fue la única encontrada; no se observó relación con tuberculosis o lupus. |
ca |
dc.format |
application/pdf |
|
dc.format.extent |
60 |
ca |
dc.language.iso |
eng |
ca |
dc.publisher |
Universitat de les Illes Balears |
|
dc.rights |
all rights reserved |
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject.other |
Mannose binding lectin |
ca |
dc.subject.other |
Mannose associated serine protease |
ca |
dc.subject.other |
Polymorphisms |
ca |
dc.subject.other |
Lupus |
ca |
dc.subject.other |
Tuberculosis |
ca |
dc.subject.other |
Manosa asociada a lectina |
ca |
dc.subject.other |
Manosas asociadas a serinproteasa |
ca |
dc.subject.other |
Polimorfismos |
ca |
dc.title |
The lectin pathway in lupus and tuberculosis: MBL2 and MASP2 polymorphisms, beneficial or harmful |
ca |
dc.type |
info:eu-repo/semantics/doctoralThesis |
|
dc.type |
info:eu-repo/semantics/publishedVersion |
|
dc.subject.udc |
61 - Medicina |
ca |
dc.subject.udc |
616.4 - Patologia del sistema limfàtic, òrgans hematopoètics, endocrins |
ca |
dc.subject.ac |
Ciencias biosociosanitarias |
ca |
dc.contributor.director |
García Gasalla, Mercedes
|
|
dc.contributor.director |
Grases Freixedas, Fèlix
|
|