Study of the inflammatory state in tumor tissue of colorectal cancer patients depending on the stage

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dc.contributor Pons Miró, Daniel Gabriel Alorda Clarà, Marina 2018 2019-07-22T10:20:19Z 2018-06-21
dc.description.abstract [eng] Colorectal cancer is the third-most common cancer worldwide and 80% of cases have an environmental origin (occidental lifestyle, inflammatory bowel diseases). The solid tumors are formed by neoplastic and stromal cells but also by a different type of immune cells, forming the tumor microenvironment. Tumor microenvironment has an associated inflammation that participates in tumor growth, angiogenesis, epithelial – mesenchymal transition and metastasis. Changes in inflammation and hypoxia levels in the tumor tissue in patients affected of colorectal cancer were studied, according to tumor stage, by the determination of protein expression levels by western blot of proteins related to inflammation and hypoxia, such as pJAK2, JAK2, pSTAT3, STAT3 (proinflammatory pathway and promote cell proliferation), NF-κB, pIκB and IκB (pro-inflammatory proteins), COX2 (pro-inflammatory and pro-angiogenic protein) and PPARγ (anti-inflammatory protein). Our results indicated a decrease of inflammation probably due to an increase of hypoxia in early colorectal cancer and the reversion of this situation, increase of inflammation probably due to a decrease of hypoxia, in advanced colorectal cancer. These results could indicate the importance of these situations in the evaluation of colorectal cancer development and progression. ca
dc.format application/pdf
dc.language.iso eng ca
dc.publisher Universitat de les Illes Balears
dc.rights all rights reserved
dc.rights info:eu-repo/semantics/openAccess
dc.subject 577 - Bioquímica. Biologia molecular. Biofísica ca
dc.subject 616 - Patologia. Medicina clínica. Oncologia ca
dc.title Study of the inflammatory state in tumor tissue of colorectal cancer patients depending on the stage ca
dc.type info:eu-repo/semantics/masterThesis ca
dc.type info:eu-repo/semantics/publishedVersion 2018-12-20T09:42:45Z info:eu-repo/date/embargoEnd/2050-01-01
dc.embargo 2050-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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