dc.contributor.author | Cedó, Lídia | |
dc.contributor.author | García-León, Annabel | |
dc.contributor.author | Baila-Rueda, Lucía | |
dc.contributor.author | Santos, David | |
dc.contributor.author | Grijalva, Victor | |
dc.contributor.author | Martínez-Cignoni, Melanie Raquel | |
dc.contributor.author | Carbó, José M. | |
dc.contributor.author | Metso, Jari | |
dc.contributor.author | López-Vilaró, Laura | |
dc.contributor.author | Zorzano, Antonio | |
dc.contributor.author | Valledor, Annabel F. | |
dc.contributor.author | Cenarro, Ana | |
dc.contributor.author | Jauhiainen, Matti | |
dc.contributor.author | Lerma, Enrique | |
dc.contributor.author | Fogelman, Alan M. | |
dc.contributor.author | Reddy, Srinivasa T. | |
dc.contributor.author | Escolà-Gil, Joan Carles | |
dc.contributor.author | Blanco-Vaca, Francisco | |
dc.date.accessioned | 2019-09-23T07:21:10Z | |
dc.date.available | 2019-09-23T07:21:10Z | |
dc.identifier.uri | http://hdl.handle.net/11201/149920 | |
dc.description.abstract | Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification. | |
dc.format | application/pdf | |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep36387 | |
dc.relation.ispartof | Scientific Reports, 2016, vol. 6, num. 36387, p. 1-11 | |
dc.rights | cc-by (c) Cedó, Lídia et al., 2016 | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | |
dc.subject.classification | 616 - Patologia. Medicina clínica. Oncologia | |
dc.subject.other | 616 - Pathology. Clinical medicine | |
dc.title | ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.date.updated | 2019-09-23T07:21:11Z | |
dc.subject.keywords | breast cancer | |
dc.subject.keywords | mice | |
dc.subject.keywords | Oxidized LDL | |
dc.subject.keywords | Apolipoprotein A-I mimetics | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.identifier.doi | https://doi.org/10.1038/srep36387 |
The following license files are associated with this item: