ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer

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dc.contributor.author Cedó, Lídia
dc.contributor.author García-León, Annabel
dc.contributor.author Baila-Rueda, Lucía
dc.contributor.author Santos, David
dc.contributor.author Grijalva, Victor
dc.contributor.author Martínez-Cignoni, Melanie Raquel
dc.contributor.author Carbó, José M.
dc.contributor.author Metso, Jari
dc.contributor.author López-Vilaró, Laura
dc.contributor.author Zorzano, Antonio
dc.contributor.author Valledor, Annabel F.
dc.contributor.author Cenarro, Ana
dc.contributor.author Jauhiainen, Matti
dc.contributor.author Lerma, Enrique
dc.contributor.author Fogelman, Alan M.
dc.contributor.author Reddy, Srinivasa T.
dc.contributor.author Escolà-Gil, Joan Carles
dc.contributor.author Blanco-Vaca, Francisco
dc.date.accessioned 2019-09-23T07:21:10Z
dc.date.available 2019-09-23T07:21:10Z
dc.identifier.uri http://hdl.handle.net/11201/149920
dc.description.abstract Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification.
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a: https://doi.org/10.1038/srep36387
dc.relation.ispartof Scientific Reports, 2016, vol. 6, num. 36387, p. 1-11
dc.rights cc-by (c) Cedó, Lídia et al., 2016
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification 616 - Patologia. Medicina clínica. Oncologia
dc.subject.other 616 - Pathology. Clinical medicine
dc.title ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-09-23T07:21:11Z
dc.subject.keywords breast cancer
dc.subject.keywords mice
dc.subject.keywords Oxidized LDL
dc.subject.keywords Apolipoprotein A-I mimetics
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.1038/srep36387

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cc-by (c) Cedó, Lídia et al., 2016 Except where otherwise noted, this item's license is described as cc-by (c) Cedó, Lídia et al., 2016