Increased rate of FEV1 decline in HIV patients despite effective treatment with HAART

Show simple item record Samperiz, Gloria Fanjul, Francisco Valera, Jose Luis Lopez, Meritxell Rios, Ángel Peñaranda, María Campins, Antoni Riera, Melchor Agusti, Alvar 2020-01-30T12:18:00Z 2020-01-30T12:18:00Z
dc.description.abstract [eng] Introduction Previous studies have reported that the rate of FEV1 decline over time is increased in HIV patients but the mechanisms underlying this observation are unclear. Since current HIV treatment with Highly Active Antiretroviral Therapy (HAART) results in very good immune-viral control, we hypothesized that HAART should normalize the elevated rate of FEV1 decline previously reported in HIV patients if it was somehow related to the immune alterations caused by HIV, particularly in never smokers or quitters, since smoking is a well established risk factor for accelerated FEV1 decline in the general population. Methods We explored this hypothesis in a prospectively recruited cohort of 188 HIV (smoker and non-smoker) patients treated with HAART in Palma de Mallorca (Spain) and followed-up for 6 years. The cross-sectional characteristics of this cohort have been published elsewhere. Results We found that: (1) HAART resulted in good immune-viral control; (2) the rate of FEV1 decline remained abnormally elevated, even in non-smokers and quitters; and, (3) alcohol abuse during follow-up was related to FEV1 decline in these patients. Discussion Despite adequate immune-viral control by HAART, lung function decline remains increased in most HIV patients, even in non-smokers and quitters. Alcohol abuse is a preventable risk factor to decrease the accelerated FEV1 decline in this population.
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dc.relation.isformatof Reproducció del document publicat a:
dc.relation.ispartof Plos One, 2019, vol. 2019, p. 1-13
dc.rights cc-by (c) Samperiz, Gloria et al., 2019
dc.subject.classification 00 - Ciència i coneixement. Investigació. Cultura. Humanitats
dc.subject.other 00 - Prolegomena. Fundamentals of knowledge and culture. Propaedeutics
dc.title Increased rate of FEV1 decline in HIV patients despite effective treatment with HAART
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion 2020-01-30T12:18:01Z
dc.rights.accessRights info:eu-repo/semantics/openAccess

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cc-by (c) Samperiz, Gloria et al., 2019 Except where otherwise noted, this item's license is described as cc-by (c) Samperiz, Gloria et al., 2019

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