Leptin distribution in rat foetal and extraembryonic tissues in late gestation: A physiological view of amniotic fluid leptin

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dc.contributor.author Yau-Qiu, Zhi Xin
dc.contributor.author Picó, Catalina
dc.contributor.author Rodríguez, Ana María
dc.contributor.author Palou, Andreu
dc.date.accessioned 2020-10-29T12:21:58Z
dc.date.available 2020-10-29T12:21:58Z
dc.identifier.uri http://hdl.handle.net/11201/154005
dc.description.abstract [eng] Prenatal leptin is key to regulating foetal growth and early metabolic programming. The presence of intact leptin in rat foetal (at late gestation) and neonatal (immediately after birth) stomach content and mucosa has been previously described, suggesting that it may act as a regulatory nutrient for the neonate rats, be internalised by the stomach, and play a physiological role early in life, which requires to be further investigated, including its origin. We aimed to study the ontogeny of the presence of leptin in the foetal stomach and key extraembryonic tissues in rats at late gestation (days 18-21). Leptin concentration was determined by enzyme-linked immunosorbent assay, and placental leptin immunolocalisation was analysed by immunohistochemistry. Leptin showed a sudden appearance in the amniotic fluid (AF) at day 20 of gestation, gastric content (swallowed AF), stomach, and umbilical cord, significantly increasing at day 21. Leptin levels in these fluids and tissues were positively correlated. In the placenta, leptin was detectable at all the studied days, but its localisation changed from widespread throughout the placenta at day 18 to well-defined in the labyrinth zone from day 19 onwards. The results support a possible internalisation of AF leptin by the immature stomach of near-term foetuses and suggest that changes in placental leptin localisation might help to explain the sudden appearance of leptin in AF at gestational day 20, with potential physiological significance regarding short-term feeding control and metabolic programming in the developing offspring.
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a: https://doi.org/10.3390/nu12092542
dc.relation.ispartof Nutrients, 2020, vol. 12, num. 9, p. 1-14
dc.rights cc-by (c) Yau-Qiu, Zhi Xin et al., 2020
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification 57 - Biologia
dc.subject.classification Ciències de la salut
dc.subject.other 57 - Biological sciences in general
dc.subject.other Medical sciences
dc.title Leptin distribution in rat foetal and extraembryonic tissues in late gestation: A physiological view of amniotic fluid leptin
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2020-10-29T12:21:59Z
dc.subject.keywords leptin
dc.subject.keywords Metabolic programming
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.3390/nu12092542


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cc-by (c) Yau-Qiu, Zhi Xin et al., 2020 Except where otherwise noted, this item's license is described as cc-by (c) Yau-Qiu, Zhi Xin et al., 2020