Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine

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dc.contributor.author Hernández, Yumaira
dc.contributor.author Costa-Bauza, Antonia
dc.contributor.author Calvó, Paula
dc.contributor.author Benejam, Joan
dc.contributor.author Sanchís, Pilar
dc.contributor.author Grases, Fèlix
dc.date.accessioned 2021-02-06T16:07:05Z
dc.date.available 2021-02-06T16:07:05Z
dc.identifier.uri http://hdl.handle.net/11201/155006
dc.description.abstract [eng] Background. Uric acid (UA) renal lithiasis has a high rate of recurrence and a prevalence ranging from 10% and 15%, depending on the population. The most important etiological factor is persistence of urinary pH below 5.5 and one of the most common treatments is alkalization with citrate. Recent studies demonstrated that theobromine, which is abundant in chocolate and cocoa, is a potent inhibitor of UA crystallization. Aim. The aim was to compare the efficacy of citrate versus citrate + theobromine as treatment for UA lithiasis. Methods. This randomized cross-over trial investigated the efficacy of two treatments in 47 patients with UA renal lithiasis. Urine volume, pH, UA excretion, theobromine excretion, and risk of UA crystallization (RUAC) at baseline and at the end of each intervention period were measured. Results. Each treatment significantly reduced the risk of UA crystallization compared to basal values. The RUAC after citrate + theobromine was lower than the RUAC after citrate, although this difference was not statistically significant. Conclusion. The combined consumption of citrate and theobromine may be a promising strategy for the prevention of UA kidney stones.
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a: https://doi.org/10.3390/nu12072012
dc.relation.ispartof Nutrients, 2020, vol. 12, num. 7, p. 1-8
dc.rights cc-by (c) Hernández, Yumaira et al., 2020
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification 54 - Química
dc.subject.classification Ciències de la salut
dc.subject.classification 57 - Biologia
dc.subject.other 54 - Chemistry. Crystallography. Mineralogy
dc.subject.other Medical sciences
dc.subject.other 57 - Biological sciences in general
dc.title Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2021-02-06T16:07:05Z
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.3390/nu12072012


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cc-by (c) Hernández, Yumaira et al., 2020 Except where otherwise noted, this item's license is described as cc-by (c) Hernández, Yumaira et al., 2020