Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats

Show simple item record Ramis, M.R. Sarubbo, F. Moranta, D. Tejada, S. Lladó, J. Miralles, A. Esteban, S. 2021-03-26T08:11:41Z 2021-03-26T08:11:41Z
dc.description.abstract [eng] Dietary recommendations are frequently developed based on nutrient deficiency or pre vention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship between diet and brain health. This work studied the effect of a diet based on foods rich in antioxidants, especially polyphenols, in rats, three days a week for 20 months starting at 14 months. Behavioral analysis testing working memory, spatial and episodic memory, as well as brain monoaminergic neurotransmitters involved in these processes but also in general brain health were analyzed. In addition, hippocampal SIRT1 protein which has an important role in regulating normal brain function was evaluated. The results show that long-term intake of polyphenol-enriched diet improves memory and learning, correlating with restoration of brain monoaminergic neuro transmitters and hippocampal SIRT1 levels in aged rats. These results agree with reports revealing a neuroprotective effect of different polyphenolic compounds on age-related brain decline, based on its antioxidant and anti-inflammatory properties; and demonstrate that consumption of antioxidant-rich foods, a few days a week, gives good long-term results in terms of brain health.
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a:
dc.relation.ispartof Nutrients, 2021, vol. 13, num. 1, p. 59 (1)-59 (14)
dc.rights cc-by (c) Ramis, M.R. et al., 2021
dc.subject.classification 57 - Biologia
dc.subject.other 57 - Biological sciences in general
dc.title Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion 2021-03-26T08:11:41Z
dc.rights.accessRights info:eu-repo/semantics/openAccess

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