Nonenzymatic reactions above phospholipid surfaces of biological membranes. Reactivity of phospholipids and their oxidation derivatives

Show simple item record Solís Calero, Christian Ortega Castro, Joaquín Frau Munar, Juan Muñoz Izquierdo, Francisco 2015-11-23T08:59:58Z 2015-11-23T08:59:58Z 2015
dc.identifier.citation 1942-0900
dc.description.abstract Phospholipids play multiple and essential roles in cells, as components of biological membranes. Although phospholipid bilayers provide the supporting matrix and surface for many enzymatic reactions, their inherent reactivity and possible catalytic role have not been highlighted. As other biomolecules, phospholipids are frequent targets of nonenzymatic modifications by reactive substances including oxidants and glycating agents which conduct to the formation of advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs). There are some theoretical studies about the mechanisms of reactions related to these processes on phosphatidylethanolamine surfaces, which hypothesize that cell membrane phospholipids surface environment could enhance some reactions through a catalyst effect. On the other hand, the phospholipid bilayers are susceptible to oxidative damage by oxidant agents as reactive oxygen species (ROS). Molecular dynamics simulations performed on phospholipid bilayers models, which include modified phospholipids by these reactions and subsequent reactions that conduct to formation of ALEs and AGEs, have revealed changes in the molecular interactions and biophysical properties of these bilayers as consequence of these reactions. Then, more studies are desirable which could correlate the biophysics of modified phospholipids with metabolism in processes such as aging and diseases such as diabetes, atherosclerosis, and Alzheimer's disease.
dc.language.iso eng
dc.publisher Hindawi Publishing Corporation
dc.relation.isformatof Reproducció del document publicat a: 10.1155/2015/319505
dc.relation.ispartof Oxidative Medicine And Cellular Longevity, 2015, vol. 2015, 23 p., num. 319595
dc.rights cc-by (c) Solis-Calero, Christian et al., 2015
dc.subject.classification Química
dc.subject.other Chemistry
dc.title Nonenzymatic reactions above phospholipid surfaces of biological membranes. Reactivity of phospholipids and their oxidation derivatives
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion 2015-11-23T08:59:58Z
dc.subject.keywords Non-enzymatic glycation
dc.subject.keywords Amino-Phospholipid
dc.subject.keywords surface chemistry
dc.subject.keywords Membranes
dc.subject.keywords DFT
dc.rights.accessRights info:eu-repo/semantics/openAccess

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cc-by (c) Solis-Calero, Christian et al., 2015 Except where otherwise noted, this item's license is described as cc-by (c) Solis-Calero, Christian et al., 2015