Hypoxic response in cancer progression: modeling HIF activation

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dc.contributor Toral Garcés, Raúl
dc.contributor Flandoli, Franco
dc.contributor.author Ferrante, Patrizia
dc.date 2020
dc.date.accessioned 2022-01-26T08:37:48Z
dc.date.issued 2020-12-11
dc.identifier.uri http://hdl.handle.net/11201/156964
dc.description.abstract [eng] The reprogramming of energy metabolism represents an important hallmark of cancer. The main cause of this alteration is represented by the presence of hypoxic areas. The decreased availability of oxygen activates the Hypoxia Inducible Factor (HIF) pathway which regulates the switch from an aerobic to an anaerobic metabolism, as well as an increased uptake of glucose. The aim of this thesis is multiple. In the first part we study and we numerically simulate a mathematical model consisting of four ordinary differential equations (ODEs): one for cancer cells with HIF inactivated, one for cancer cells with HIF activated and two for the metabolites cancer cells can consume in order to produce ATP. We model the dynamics of the transition between the two different behaviors, of cancer growth under normoxic and hypoxic conditions and of cancer progression in a hostile environment; furthermore we compare the behaviour of cancer cells in highlanders and lowlanders. In the second part we introduce a simple mathematical model to analyse the link between angiogenesis and the Warburg effect in cancer cells. We show that the the increased expression of glucose receptor is an important factor in the transition from initiation to cancer progression . We also show that the genetic polymorphism considered in highlanders does not provide useful information on cancer growth in the long term behaviour. The second model, despite only introduced, will let us formulate new questions concerning the role of the angiogenesis in cancer progression and fascinating links among different aspect of cancer metabolism. ca
dc.format application/pdf
dc.language.iso eng ca
dc.publisher Universitat de les Illes Balears
dc.rights all rights reserved
dc.rights info:eu-repo/semantics/openAccess
dc.subject 616 - Patologia. Medicina clínica. Oncologia ca
dc.subject.other Cancer progression ca
dc.subject.other HIF pathway ca
dc.subject.other angiogenesis ca
dc.title Hypoxic response in cancer progression: modeling HIF activation ca
dc.type info:eu-repo/semantics/masterThesis ca
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2021-06-30T11:13:27Z
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2050-01-01
dc.embargo 2050-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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