[eng] Objectives: The antibacterial activity of zinc oxide (ZnO) and silver (Ag) nanoparticles (NPs) has been investigated in this study to present achievements in this field with the consensus of outcomes. This systematic review and meta-analysis clarified the antibacterial potential of silver, zinc-oxide NPs-coated Orthodontic Brackets. Methods: PRISMA 2020 Checklist was the basis for performing the current systematic review and meta-analysis. The search strategy was to screen the relevant databases on PubMed, Embase, Web of Science, Scopus, ISI Web of knowledge, and EBSCO from inception until 1 November 2022. We calculated a 95% confidence interval (95%CI) for the mean difference (MD) based on the fixed effect model and Inverse variance method. Stata/MP version 17 software was applied to conduct the meta analysis. Results: In the initial search, duplicate studies were removed, and the abstracts of 209 separate relevant articles were presented. Two individual authors reviewed the full text of 32 articles, resulting in the final eight articles. The mean difference (MD) of the antibacterial effect of bracket coatings against L. acidophilus between AgNPs coating and the controls was estimated at 2.71 (MD, 2.71 95%CI 2.05-3.37; p=0.00). The mean difference (MD) of the antibacterial potential of bracket coatings against S. mutans between ZnONPs coating and the controls was estimated to be -275.54 (MD, -275.54 95%CI -281.23, -269.85; p=0.00). Conclusions: The results of our meta-analysis revealed that Ag, ZnO, and Ag/ZnO NPs-coated brackets had antibacterial activity against L. acidophilus and S. mutans compared to uncoated brackets.