Introducing a squaramide-based self-immolative spacer for controlled drug release

Ximenis, Marta; Sampedro, Angel; Martinez, Luis; Ramis, Guillem; Orvay, Francisca; Costa, Antonio; Rotger, Carmen

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dc.contributor.author	Ximenis, Marta
dc.contributor.author	Sampedro, Angel
dc.contributor.author	Martinez, Luis
dc.contributor.author	Ramis, Guillem
dc.contributor.author	Orvay, Francisca
dc.contributor.author	Costa, Antonio
dc.contributor.author	Rotger, Carmen
dc.date.accessioned	2023-12-21T09:13:42Z
dc.date.available	2023-12-21T09:13:42Z
dc.identifier.uri	http://hdl.handle.net/11201/163292
dc.description.abstract	[eng] Herein we report the design, synthesis and assessment of the first example of a squaramide-based self-immolative system triggered by an enzymatic reduction. We have proved that the release of the alkylating agent N′,N′-(bis(2-chloroethyl)benzene)-1,4-diamine (ANM) provokes a dramatic reduction of the survival factor in glioblastoma cells, evidencing the suitability of the squaramide-based spacer for drug delivery applications.
dc.format	application/pdf
dc.relation.isformatof	Versió postprint del document publicat a: https://doi.org/10.1039/D0CC07683J
dc.relation.ispartof	Chemical Communications, 2021, vol. 57, num. 22, p. 2736-2739
dc.rights	(c) Ximenis, Marta et al., 2021
dc.subject.classification	54 - Química
dc.subject.classification	57 - Biologia
dc.subject.other	54 - Chemistry. Crystallography. Mineralogy
dc.subject.other	57 - Biological sciences in general
dc.title	Introducing a squaramide-based self-immolative spacer for controlled drug release
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.date.updated	2023-12-21T09:13:42Z
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.identifier.doi	https://doi.org/10.1039/D0CC07683J