An intercommunicated nanosystem for dual delivery

Show simple item record Mayol, Beatriz Rodríguez, Ana Villalonga, Anabel Anillo, Carlos Vilela, Diana Sánchez, Alfredo Martínez-Ruiz, Paloma Villalonga, Reynaldo 2024-04-09T10:37:39Z
dc.description.abstract [eng] Here, we describe the design of a novel particle-to-particle intercommunicated nanosystem for dual delivery, triggered by physical and chemical inputs. The nanosystem was composed of an Au-mesoporous silica Janus nanoparticle loaded with paracetamol, mechanized with light-sensitive supramolecular gates at the mesoporous face and functionalized on the metal surface with the enzyme acetylcholinesterase. The second component was a mesoporous silica nanoparticle loaded with rhodamine B and gated with thiol-sensitive ensembles. Upon irradiation of this nanosystem with a near-UV light laser, an analgesic drug was released from the Janus nanomachine due to disassembling of the photosensitive gating mechanism. Further addition of N-acetylthiocholine leads to the enzymatic production of thiocholine at the Janus nanomachine, thus acting as a 'chemical messenger' causing the disruption of the gating mechanism at the second mesoporous silica nanoparticle with the subsequent dye release.
dc.format application/pdf
dc.relation.ispartof Journal Of Materials Chemistry B, 2023, vol. 11, num. 30, p. 7190-7196
dc.rights , 2023
dc.subject.classification 57 - Biologia
dc.subject.classification Ciències de la salut
dc.subject.other 57 - Biological sciences in general
dc.subject.other Medical sciences
dc.title An intercommunicated nanosystem for dual delivery
dc.type info:eu-repo/semantics/article 2024-04-09T10:37:40Z info:eu-repo/date/embargoEnd/2100-01-01
dc.embargo 2100-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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