dc.contributor.author |
Mayol, Beatriz |
|
dc.contributor.author |
Rodríguez, Ana |
|
dc.contributor.author |
Villalonga, Anabel |
|
dc.contributor.author |
Anillo, Carlos |
|
dc.contributor.author |
Vilela, Diana |
|
dc.contributor.author |
Sánchez, Alfredo |
|
dc.contributor.author |
Martínez-Ruiz, Paloma |
|
dc.contributor.author |
Villalonga, Reynaldo |
|
dc.date.accessioned |
2024-04-09T10:37:39Z |
|
dc.identifier.uri |
http://hdl.handle.net/11201/165319 |
|
dc.description.abstract |
[eng] Here, we describe the design of a novel particle-to-particle intercommunicated nanosystem for dual delivery, triggered by physical and chemical inputs. The nanosystem was composed of an Au-mesoporous silica Janus nanoparticle loaded with paracetamol, mechanized with light-sensitive supramolecular gates at the mesoporous face and functionalized on the metal surface with the enzyme acetylcholinesterase. The second component was a mesoporous silica nanoparticle loaded with rhodamine B and gated with thiol-sensitive ensembles. Upon irradiation of this nanosystem with a near-UV light laser, an analgesic drug was released from the Janus nanomachine due to disassembling of the photosensitive gating mechanism. Further addition of N-acetylthiocholine leads to the enzymatic production of thiocholine at the Janus nanomachine, thus acting as a 'chemical messenger' causing the disruption of the gating mechanism at the second mesoporous silica nanoparticle with the subsequent dye release. |
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dc.format |
application/pdf |
|
dc.relation.isformatof |
https://doi.org/10.1039/d3tb00512g |
|
dc.relation.ispartof |
Journal Of Materials Chemistry B, 2023, vol. 11, num. 30, p. 7190-7196 |
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dc.rights |
, 2023 |
|
dc.subject.classification |
57 - Biologia |
|
dc.subject.classification |
Ciències de la salut |
|
dc.subject.other |
57 - Biological sciences in general |
|
dc.subject.other |
Medical sciences |
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dc.title |
An intercommunicated nanosystem for dual delivery |
|
dc.type |
info:eu-repo/semantics/article |
|
dc.date.updated |
2024-04-09T10:37:40Z |
|
dc.date.embargoEndDate |
info:eu-repo/date/embargoEnd/2100-01-01 |
|
dc.embargo |
2100-01-01 |
|
dc.rights.accessRights |
info:eu-repo/semantics/embargoedAccess |
|
dc.identifier.doi |
https://doi.org/10.1039/d3tb00512g |
|