Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm: A potential therapeutic opportunity?

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dc.contributor.author Puertas-Umbert, L.
dc.contributor.author Varona, S.
dc.contributor.author Ballester-Servera, C.
dc.contributor.author Alonso, J.
dc.contributor.author Aguiló, S.
dc.contributor.author Orriols, M.
dc.contributor.author Martínez-Martínez, E.
dc.contributor.author Rodríguez-Sinovas, A.
dc.contributor.author Martínez-González, J.
dc.contributor.author Rodríguez, C.
dc.date.accessioned 2025-02-05T08:11:33Z
dc.date.available 2025-02-05T08:11:33Z
dc.identifier.citation Puertas-Umbert, L., Varona, S., Ballester-Servera, C., Alonso, J.; Aguiló, S., Orriols, M., Martínez-Martínez, E., Rodríguez-Sinovas, A., Martínez-González, J. i Rodríguez, C. (2022). Genes i Diseases, 10(3), 639-642. https://doi.org/10.1016/j.gendis.2022.05.017
dc.identifier.uri http://hdl.handle.net/11201/168564
dc.description.abstract [eng] Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease with a prevalence up to 8% in males over 60 years of age.1 This is a complex disorder characterized by permanent and focal dilation of abdominal aorta that exceeds at least 50% of the normal diameter. In these patients, the aortic diameter progressively expands boosted by smoking and aging as major risk factors. Unfortunately, aneurysm growth increases the risk of aortic rupture, a life-threatening emergency that carries a mortality rate of 80%. Despite the increasing effort of the scientific community to identify therapeutic strategies for AAA, there are currently no pharmacological tools that ameliorate aneurysm expansion, while the underlying mechanisms involved in this disease are not completely understood.
dc.format application/pdf
dc.format.extent 639-642
dc.publisher Elsevier
dc.relation.ispartof Genes & Diseases, 2022, vol. 10, num.3, p. 639-642
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classification 61 - Medicina
dc.subject.other 61 - Medical sciences
dc.title Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm: A potential therapeutic opportunity?
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/pusblishedVersion
dc.type Article
dc.date.updated 2025-02-05T08:11:33Z
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.1016/j.gendis.2022.05.017


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