Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer

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dc.contributor.author Gaya-Bover, A.
dc.contributor.author Hernández-López, R.
dc.contributor.author Alorda-Clara, M.
dc.contributor.author Ibarra de la Rosa, J.M.
dc.contributor.author Falcó, E.
dc.contributor.author Fernández, T.
dc.contributor.author Company, M.M.
dc.contributor.author Torrens-Mas, M.
dc.contributor.author Roca, P.
dc.contributor.author Oliver, J.
dc.contributor.author Sastre-Serra, J.
dc.contributor.author Pons, D.G.
dc.date.accessioned 2025-03-18T09:38:48Z
dc.identifier.citation Gaya-Bover, A., Hernández-López, R., Alorda-Clara, M., Ibarra de la Rosa, J.M., Falcó, E., Fernández, T., Company, M.M., Torrens-Mas, M., Roca, P., Oliver, J., Sastre-Serra, J., i Pons, D.G. (2020). Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer. International Journal of Biochemistry & Cell Biology, 120(105698). https://doi.org/10.1016/j.biocel.2020.105698 ca
dc.identifier.uri http://hdl.handle.net/11201/169466
dc.description.abstract [eng] Antioxidant defences and oxidative stress are related to development, progression and malignancy of colorectal cancer. However, their role in early stages of cancer remains unknown. More and more recent studies have revealed that non-tumour adjacent tissue is not a normal tissue. Thus, our aim was to analyse protein levels of MnSOD (Manganese Superoxide Dismutase), acMnSOD (Acetylated Manganese superoxide Dismutase), SIRT3 (Sirtuin 3), CuZnSOD (Cupper Zinc Superoxide Dismutase), CAT (Catalase), GPx (Glutathione Peroxidase), and GRd (Glutathione Reductase) both in tumour and non-tumour adjacent tissue from colorectal cancer patients by western blot. Non-tumour adjacent tissue seemed to have higher levels of antioxidant enzymes that detoxify hydrogen peroxide compared to tumour tissue. In contrast, tumour tissue had higher levels of MnSOD and acMnSOD. Furthermore, most of the proteins analysed showed significant differences between stage I and II in both non-tumour adjacent and tumour tissue. This could indicate that antioxidant enzymes, especially MnSOD, play a crucial role in early stages of colorectal cancer in both tissues, so they could be analysed as novel biomarkers to improve colorectal cancer diagnosis. en
dc.format application/pdf
dc.publisher Elsevier
dc.relation.ispartof International Journal of Biochemistry & Cell Biology, 2020, vol. 120, num. 105698
dc.rights all rights reserved
dc.subject.classification 577 - Bioquímica. Biologia molecular. Biofísica
dc.subject.other 577 - Material bases of life. Biochemistry. Molecular biology. Biophysics
dc.title Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer en
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion
dc.type Article
dc.date.updated 2025-03-18T09:38:49Z
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2100-01-01
dc.embargo 2100-01-01
dc.subject.keywords Non-tumor adjacent tissue
dc.subject.keywords colorectal cancer
dc.subject.keywords Manganese-superoxide dismutase
dc.subject.keywords oxidative stress
dc.subject.keywords antioxidant enzymes
dc.rights.accessRights info:eu-repo/semantics/closedAccess
dc.identifier.doi https://doi.org/10.1016/j.biocel.2020.105698


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