dc.contributor.author | Lucas, Xavier | |
dc.contributor.author | Bauzá Riera, Antonio | |
dc.contributor.author | Frontera Beccaria, Antonio | |
dc.contributor.author | Quiñonero Santiago, David | |
dc.date.accessioned | 2016-02-02T10:12:11Z | |
dc.date.available | 2016-02-02T10:12:11Z | |
dc.date.issued | 2015-06-05 | |
dc.identifier.citation | 2041-6520 | |
dc.identifier.uri | http://hdl.handle.net/11201/1766 | |
dc.description.abstract | Noncovalent interactions have a constitutive role in the science of intermolecular relationships, particularly those involving aromatic rings such as π-π and cation-π. In recent years, anion-π contact has also been recognized as a noncovalent bonding interaction with important implications in chemical processes. Yet, its involvement in biological processes has been scarcely reported. Herein we present a large-scale PDB analysis of the occurrence of anion-π interactions in proteins and nucleic acids. In addition we have gone a step further by considering the existence of cooperativity effects through the inclusion of a second noncovalent interaction, i.e. π-stacking, T-shaped, or cation-π interactions to form anion-π-π and anion-π-cation triads. The statistical analysis of the thousands of identified interactions reveals striking selectivities and subtle cooperativity effects among the anions, π-systems, and cations in a biological context. The reported results stress the importance of anion-π interactions and the cooperativity that arises from ternary contacts in key biological processes, such as protein folding and function and nucleic acids-protein and protein-protein recognition. We include examples of anion-π interactions and triads putatively involved in enzymatic catalysis, epigenetic gene regulation, antigen-antibody recognition, and protein dimerization. | |
dc.language.iso | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1039/C5SC01386K | |
dc.relation.ispartof | Chemical Science, 2015, vol. 2016, num. 7, p. 1038-1050 | |
dc.rights | cc-by (c) Lucas, Xavier et al., 2015 | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | |
dc.subject.classification | Química | |
dc.subject.other | Chemistry | |
dc.title | A thorough anion-π interaction study in biomolecules: on the importance of cooperativity effects | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.date.updated | 2016-02-02T10:12:11Z | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.identifier.doi | http://dx.doi.org/10.1039/C5SC01386K |
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