Effects of active compounds present in beer on oxidative stress in colon cancer cells

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dc.contributor Sastre Serra, Jorge
dc.contributor Pons Miró, Daniel Gabriel
dc.contributor.author Martínez Vigara, María
dc.date 2019
dc.date.accessioned 2020-02-14T10:50:52Z
dc.date.issued 2019-07-03
dc.identifier.uri http://hdl.handle.net/11201/150894
dc.description.abstract [eng] Xanthohumol (XN) is the major prenylated flavonoid present in the hops and has been related to multiple beneficial properties. XN and their derivatives (isoxanthohumol (IXN) and 8-prenylnaringenin (8PN)) have been studied to evaluate their chemopreventive and chemotherapeutic potential against different cancers. Colorectal cancer is the third most diagnosed cancer worldwide and the fourth most common cause of cancer death worldwide. The purpose of this study was to determine if these phytochemicals (XN, IXN and 8PN) could affect cellular proliferation and oxidative stress through regulation of antioxidant enzymes genes or protein expression in colorectal cancer cells. Different concentrations of XN, IXN and 8PN were added to HT29 and SW620 colorectal cancer cell lines to understand the role of this bioactive compounds in ROS production, cell viability, and gene expression of antioxidant enzymes (sod1, sod2, gpx, grd and cat). The metastatic SW620 cell line showed an increase in ROS production and a decrease in cell viability after XN treatment. Moreover, catalase was decreased, and lipid peroxidation was increased. In contrast, primary tumour HT29 cells did notshow biologically relevant differences in cell viability, ROS production or protein expression of antioxidant enzymes, but the gene expressions of this proteins were decreased after XN treatment, and lipid peroxidation was also decreased. These results suggest that XN, but not IXN or 8PN, at high concentrations, increase oxidative stress due to, in part, a deregulation of catalase expression, leading to cell death. ca
dc.format application/pdf
dc.language.iso eng ca
dc.publisher Universitat de les Illes Balears
dc.rights all rights reserved
dc.rights info:eu-repo/semantics/openAccess
dc.subject 61 - Medicina ca
dc.subject 616 - Patologia. Medicina clínica. Oncologia ca
dc.title Effects of active compounds present in beer on oxidative stress in colon cancer cells ca
dc.type info:eu-repo/semantics/masterThesis ca
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2019-11-29T10:56:33Z
dc.date.embargoEndDate info:eu-repo/date/embargoEnd/2050-01-01
dc.embargo 2050-01-01
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess

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