Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging

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dc.contributor.author Terrasa, J.L.
dc.contributor.author Montoya, P.
dc.contributor.author Sitges, C.
dc.contributor.author van der Meulen, M.
dc.contributor.author Anton, F.
dc.contributor.author González-Roldán, A.M.
dc.date.accessioned 2021-11-16T07:43:59Z
dc.date.available 2021-11-16T07:43:59Z
dc.identifier.uri http://hdl.handle.net/11201/156154
dc.description.abstract [eng] Alterations in the affective component of pain perception are related to the development of chronic pain and may contribute to the increased vulnerability to pain observed in aging. The present study analyzed age-related changes in resting-state brain activity and their possible relation to an increased pain perception in older adults. For this purpose, we compared EEG current source density and fMRI functional-connectivity at rest in older (n = 20, 66.21 3.08 years) and younger adults (n = 21, 20.71 2.30 years) and correlated those brain activity parameters with pain intensity and unpleasantness ratings elicited by painful stimulation. We found an age-related increase in beta2 and beta3 activity in temporal, frontal, and limbic areas, and a decrease in alpha activity in frontal areas. Moreover, older participants displayed increased functional connectivity in the anterior cingulate cortex (ACC) and the insula with precentral and postcentral gyrus. Finally, ACC beta3 activity was positively correlated with pain intensity and unpleasantness ratings in older, and ACC-precentral/postcentral gyrus connectivity was positively correlated with unpleasantness ratings in older and younger participants. These results reveal that ACC resting-state hyperactivity is a stable trait of brain aging and may underlie their characteristic altered pain perception.
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2021.695200
dc.relation.ispartof Frontiers In Aging Neuroscience, 2021, vol. 13, num. 695200
dc.rights cc-by (c) Terrasa, J.L. et al., 2021
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification 159.9 - Psicologia
dc.subject.other 159.9 - Psychology
dc.title Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2021-11-16T07:44:00Z
dc.subject.keywords aging
dc.subject.keywords pain
dc.subject.keywords EEG
dc.subject.keywords fMRI
dc.subject.keywords resting-state networks
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.3389/fnagi.2021.695200


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cc-by (c) Terrasa, J.L. et al., 2021 Except where otherwise noted, this item's license is described as cc-by (c) Terrasa, J.L. et al., 2021

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