dc.contributor.author | González-Roldán, A.M. | |
dc.contributor.author | Terrasa, J.L. | |
dc.contributor.author | Sitges, C. | |
dc.contributor.author | van der Meulen, M. | |
dc.contributor.author | Anton, F. | |
dc.contributor.author | Montoya, P. | |
dc.date.accessioned | 2021-11-16T08:24:22Z | |
dc.date.available | 2021-11-16T08:24:22Z | |
dc.identifier.uri | http://hdl.handle.net/11201/156155 | |
dc.description.abstract | [eng] Aging affects pain experience and brain functioning. However, how aging leads to changes in pain perception and brain functional connectivity has not yet been completely understood. To investigate resting-state and pain perception changes in old and young participants, this study employed region of interest (ROI) to ROI resting-state functional connectivity (rsFC) analysis of imaging data by using regions implicated in sensory and affective dimensions of pain, descending pain modulation, and the default-mode networks (DMNs). Thirty-seven older (66.86 ± 4.04 years; 16 males) and 38 younger healthy participants (20.74 ± 4.15 years; 19 males) underwent 10 min' eyes-closed resting-state scanning. We examined the relationship between rsFC parameters with pressure pain thresholds. Older participants showed higher pain thresholds than younger. Regarding rsFC, older adults displayed increased connectivity of pain-related sensory brain regions in comparison to younger participants: increased rsFC between bilateral primary somatosensory area (SI) and anterior cingulate cortex (ACC), and between SI(L) and secondary somatosensory area (SII)-(R) and dorsolateral prefrontal cortex (PFC). Moreover, decreased connectivity in the older compared to the younger group was found among descending pain modulatory regions: between the amygdala(R) and bilateral insula(R), thalamus(R), ACC, and amygdala(L); between the amygdala(L) and insula(R) and bilateral thalamus; between ACC and bilateral insula, and between periaqueductal gray (PAG) and bilateral thalamus. Regarding the DMN, the posterior parietal cortex and lateral parietal (LP; R) were more strongly connected in the older group than in the younger group. Correlational analyses also showed that SI(L)-SII(R) rsFC was positively associated with pressure pain thresholds in older participants. In conclusion, these findings suggest a compensatory mechanism for the sensory changes that typically accompanies aging. Furthermore, older participants showed reduced functional connectivity between key nodes of the descending pain inhibitory pathway. | |
dc.format | application/pdf | |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2020.00116 | |
dc.relation.ispartof | Frontiers In Aging Neuroscience, 2020, vol. 12, num. 116, p. 1-10 | |
dc.rights | cc-by (c) González-Roldán, A.M. et al., 2020 | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | |
dc.subject.classification | 159.9 - Psicologia | |
dc.subject.other | 159.9 - Psychology | |
dc.title | Age-related changes in pain perception are associated with altered functional connectivity during resting state | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.date.updated | 2021-11-16T08:24:23Z | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.identifier.doi | https://doi.org/10.3389/fnagi.2020.00116 |
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