Age-related changes in pain perception are associated with altered functional connectivity during resting state

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dc.contributor.author González-Roldán, A.M.
dc.contributor.author Terrasa, J.L.
dc.contributor.author Sitges, C.
dc.contributor.author van der Meulen, M.
dc.contributor.author Anton, F.
dc.contributor.author Montoya, P.
dc.date.accessioned 2021-11-16T08:24:22Z
dc.date.available 2021-11-16T08:24:22Z
dc.identifier.uri http://hdl.handle.net/11201/156155
dc.description.abstract [eng] Aging affects pain experience and brain functioning. However, how aging leads to changes in pain perception and brain functional connectivity has not yet been completely understood. To investigate resting-state and pain perception changes in old and young participants, this study employed region of interest (ROI) to ROI resting-state functional connectivity (rsFC) analysis of imaging data by using regions implicated in sensory and affective dimensions of pain, descending pain modulation, and the default-mode networks (DMNs). Thirty-seven older (66.86 ± 4.04 years; 16 males) and 38 younger healthy participants (20.74 ± 4.15 years; 19 males) underwent 10 min' eyes-closed resting-state scanning. We examined the relationship between rsFC parameters with pressure pain thresholds. Older participants showed higher pain thresholds than younger. Regarding rsFC, older adults displayed increased connectivity of pain-related sensory brain regions in comparison to younger participants: increased rsFC between bilateral primary somatosensory area (SI) and anterior cingulate cortex (ACC), and between SI(L) and secondary somatosensory area (SII)-(R) and dorsolateral prefrontal cortex (PFC). Moreover, decreased connectivity in the older compared to the younger group was found among descending pain modulatory regions: between the amygdala(R) and bilateral insula(R), thalamus(R), ACC, and amygdala(L); between the amygdala(L) and insula(R) and bilateral thalamus; between ACC and bilateral insula, and between periaqueductal gray (PAG) and bilateral thalamus. Regarding the DMN, the posterior parietal cortex and lateral parietal (LP; R) were more strongly connected in the older group than in the younger group. Correlational analyses also showed that SI(L)-SII(R) rsFC was positively associated with pressure pain thresholds in older participants. In conclusion, these findings suggest a compensatory mechanism for the sensory changes that typically accompanies aging. Furthermore, older participants showed reduced functional connectivity between key nodes of the descending pain inhibitory pathway.
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2020.00116
dc.relation.ispartof Frontiers In Aging Neuroscience, 2020, vol. 12, num. 116, p. 1-10
dc.rights cc-by (c) González-Roldán, A.M. et al., 2020
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification 159.9 - Psicologia
dc.subject.other 159.9 - Psychology
dc.title Age-related changes in pain perception are associated with altered functional connectivity during resting state
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2021-11-16T08:24:23Z
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.3389/fnagi.2020.00116


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cc-by (c) González-Roldán, A.M. et al., 2020 Except where otherwise noted, this item's license is described as cc-by (c) González-Roldán, A.M. et al., 2020

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