Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial

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dc.contributor.author Cosmo, Camila
dc.contributor.author Ferrerira, Cándida
dc.contributor.author Miranda, José Garcia Vivas
dc.contributor.author Rosário, Raphael Silva do
dc.contributor.author Baptista, Abrahão Fontes
dc.contributor.author Montoya Jiménez, Pedro José
dc.contributor.author Sena, Eduardo Pondé de
dc.date.accessioned 2016-01-27T08:03:58Z
dc.date.available 2016-01-27T08:03:58Z
dc.date.issued 2015-08-04
dc.identifier.citation 1664-0640
dc.identifier.uri http://hdl.handle.net/11201/1703
dc.description.abstract Background: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attention-deficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated. Objective: The aim of this study was to investigate a functional cortical network (FCN) model based on electroencephalographic activity for studying the dynamic patterns of brain connectivity modulated by tDCS and the distribution of its effects in individuals with ADHD. Methods: Sixty ADHD patients participated in a parallel, randomized, double-blind, sham-controlled trial. Individuals underwent a single session of sham or anodal tDCS at 1 mA of current intensity over the left dorsolateral prefrontal cortex for 20 min. The acute effects of stimulation on brain connectivity were assessed using the FCN model based on electroencephalography activity. Results: Comparing the weighted node degree within groups prior to and following the intervention, a statistically significant difference was found in the electrodes located on the target and correlated areas in the active group (p < 0.05), while no statistically significant results were found in the sham group (p ≥ 0.05; paired-sample Wilcoxon signed-rank test). Conclusion: Anodal tDCS increased functional brain connectivity in individuals with ADHD compared to data recorded in the baseline resting state. In addition, although some studies have suggested that the effects of tDCS are selective, the present findings show that its modulatory activity spreads. Further studies need to be performed to investigate the dynamic patterns and physiological mechanisms underlying the modulatory effects of tDCS.
dc.language.iso eng
dc.publisher Frontiers
dc.relation.isformatof Reproducció del document publicat a: http://dx.doi.org/10.3389/fpsyt.2015.00111
dc.relation.ispartof Frontiers in Psychiatry, 2015, vol. 6, num. 111
dc.rights cc-by (c) Cosmo, Camila et al., 2015
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es
dc.subject.classification Psicologia
dc.subject.other Psychology
dc.title Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-01-27T08:03:59Z
dc.subject.keywords ADHD
dc.subject.keywords tDCS
dc.subject.keywords brain
dc.subject.keywords neural network
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2015.00111

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cc-by (c) Cosmo, Camila et al., 2015 Except where otherwise noted, this item's license is described as cc-by (c) Cosmo, Camila et al., 2015

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